Sara H Ph.D.

STATISTICAL GENETICIST
Quantitative Genetics
Genetic Epidemiology
Genotypic and Haplotype Tests
Hardy-Weinberg equilibrium
Genome-Wide Association Studies
Golden Helix
R Statistics – R Programming

clinical medical writing - clinical report writing - medical writing in clinical research - clinical protocol writing - writing clinical notes - clinical trial protocol writing - protocol writing in clinical research - clinical study report writing - writing clinical study reports - writing clinical objectives

Education

Ph.D. in Human Genetics
Thesis: Evidence for single nucleotide polymorphisms having a non-additive influence within the Apolipoprotein E gene

M.A. in Statistics

B.A. in Biology and Mathematics

Postdoctoral Training

Research Associate, Rockefeller University, New York, NY, Laboratory of Statistical Genetics, Dr. Jurg Ott

Senior Research Associate, University of Michigan, Ann Arbor, MI, Department of Human Genetics, Department of Epidemiology

Editorial Boards: 2011 Case Reports in Genetics

Awards and Honors
Genetics Training Grant
Tri Beta, National Honor Society for Biology
National Physical Sciences Scholarship
American Association of University Women Scholarship

Teaching Experience
Population & Statistical Genetics
Introduction to Statistical Reasoning
Mathematics Tutor

Consulting Experience
Consulted with graduate students, researchers and head of labs in the areas of the genetics of drug addiction (Rockefeller University), age related macular degeneration (Casey Eye Institute) and personality traits (Baylor College of Medicine). This included working with over 15 scientists.

Helped students learn and complete statistics for their dissertations, statistical classes, preliminary exams, presentations and posters.

Articles

Evidence for Consistent Intragenic and Intergenic Interactions between SNP Eff ects in the APOA1/C3/A4/A5 Gene Cluster

Evidence for Non-additive Influence of Single Nucleotide Polymorphisms within the Apolipoprotein E Gene

Publications
Levran O, Peles E, Hamon S, Randesi M, Zhao C, Zhang B, Adelson M, Kreek MJ. (2011) Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment. Pharmacogenomics J.

Ray B, Jackson C, Ducat E, Ho A, Hamon S, Kreek MJ. (2011) Effect of ethnicity, gender and drug use history on achieving high rates of affirmative informed consent for genetics research: impact of sharing with a national repository J Med Ethics.

Crystal, H., Hamon, S., Randesi, M., Cook, J., Anastos, K., Lazar, J., Liu, C., Pearce, L., Golub, E., Valcour, V., Weber, K., Holman, S., Ho, A., and Kreek, M.J. (2010) A C17T polymorphism in the mu opiate receptor is associated with quantitative measures of drug use in African-American women. Addict. Biol.

Yuferov, V., Nielsen, D.A., Levran, O., Randesi, M., Hamon, S., Ho, A., Morgello, S., and Kreek, M.J. (2010) Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs. Pharmacogenet. Genom., 21(4):185-96.

Klein ML, Ferris FL 3rd, Francis PJ, Lindblad AS, Chew EY, Hamon SC, Ott J. (2010) Progression of Geographic Atrophy and Genotype in Age-Related Macular Degeneration. Ophthalmology. 117(8):1554-9

Nielsen DA, Hamon S, Yuferov V, Jackson C, Ho A, Ott J, Kreek MJ. (2010) Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Hum Genet. 127(6):639-49

Proudnikov D, Kroslak T, Sipe JC, Randesi M, Li D, Hamon S, Ho A, Ott J, Kreek MJ. (2010) Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. Pharmacogenomics J. 10(3):232-42.

He C, Hamon S, Li D, Barral-Rodriguez S, Ott J; (2009) MHC fine mapping of human type 1 diabetes using the T1DGC data. Diabetes Genetics Consortium. Diabetes Obes Metab. Suppl 1:53-9.

Francis PJ, Hamon SC, Ott J, Weleber RG, Klein ML. (2009) Polymorphisms in C2, CFB and C3 are associated with progression to Advanced Age-Related Macular Degeneration associated with visual loss. J Med Genet. 46(5):300-7.

Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K. (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 359(14):1456-63.

Nielsen DA, Yuferov V, Hamon S, Jackson C, Ho A, Ott J, Kreek MJ. (2008) Increased OPRM1 DNA Methylation in Lymphocytes of Methadone-Maintained Former Heroin Addicts. Neuropsychopharmacology. 34(4):867-73.

Francis PJ, Appukuttan B, Simmons E, Landauer N, Stoddard J, Hamon S, Ott J, Ferguson B, Klein M, Stout JT, Neuringer M. (2008) Rhesus monkeys and humans share common susceptibility genes for age-related macular disease. Hum Mol Genet. 1;17(17):2673-80.

Klein ML, Francis PJ, Rosner B, Reynolds R, Hamon SC, Schultz DW, Ott J, Seddon JM. (2008) CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology.115(6):1019-25.

Proudnikov D, Hamon S, Ott J, Kreek MJ. (2008) Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction.
Neurosci Lett. 435(3):234-9.

Francis PJ, Schultz DW, Hamon S, Ott J, Weleber RG, Klein ML. (2007) Haplotypes in the Complement Factor H (CFH) Gene: Associations with Drusen and Advanced Age-Related Macular Degeneration. PLoS ONE. 2(11):e1197.

Kardia SL, Sun YV, Hamon SC, Barkley RA, Boerwinkle E, Turner ST. (2007) Interactions between the adducin 2 gene and antihypertensive drug therapies in determining blood pressure in people with hypertension. BMC Med Genet.13;8:61.

Francis PJ, George S, Schultz DW, Rosner B, Hamon S, Ott J, Weleber RG, Klein ML, Seddon JM. (2007) The LOC387715 Gene, Smoking, Body Mass Index, Environmental Associations with Advanced Age-Related Macular Degeneration. Hum Hered. 63(3-4):212-8.

Hamon SC, Kardia SL, Boerwinkle E, Liu K, Klos KL, Clark AG, Sing CF. (2006) Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene cluster. Hum Hered. 61(2):87-96.

Klos KL, Sing CF, Boerwinkle E, Hamon SC, Rea TJ, Clark A, Fornage M, Hixson JE. (2006) Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. Arterioscler Thromb Vasc Biol. 26(8):1828-36.

Brown CM, Rea TJ, Hamon SC, Hixson JE, Boerwinkle E, Clark AG, Sing CF. (2006) The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL-C variability. J Mol Med. Jul;84(7):561-72.

Stengard JH, Kardia SL, Hamon SC, Frikke-Schmidt R, Tybjaerg-Hansen A, Salomaa V, Boerwinkle E, Sing CF. (2006) Contribution of regulatory and structural variations in APOE to predicting dyslipidemia. J Lipid Res. 47(2):318-28.

Klos KL, Hamon S, Clark AG, Boerwinkle E, Liu K, Sing CF (2005) APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study. J Lipid Res. 46(3):564-71.

Hamon SC, Stengard JH, Clark AG, Salomaa V, Boerwinkle E, Sing CF. (2005) Evidence for non-additivity influence of single nucleotide polymorphisms within the apolipoprotein E gene. Ann Hum Genet 68:521-35.

Klos KL, Hamon S, Clark AG, Boerwinkle E, Liu K, Sing CF (2004) APOA5 polymorphisms influence plasma trigylcerides in young, healthy African Americans and whites of the CARDIA Study. J Lipid Res 46(3): 564-71.

Hamon SC (2003) Evidence for single nucleotide polymorphisms having a non-additive influence within the apolipoprotein E gene. Ph.D. Dissertation. University of Michigan. Ann Arbor, MI

Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A (2003) Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci USA 100:4066-4071.

Abstracts

Howard, C. Olaoluwakitan Awolesi, S Hamon, E Ducat, M Randesi, J Rotrosen, P Casadonte, S Linzy, M Adelson, M J Kreek, O Levran. (2010). Association study between the OPRM1 polymorphism 17C>T and heroine or cocaine addiction in African Americans. CPDD 72nd Annual Scientific Meeting, Scottsdale, Arizona.

Lorena Maili, D N Nielsen, S Liu, S Hamon, K A Cunningham, F G Moeller. (2010). Serotonin transporter polymorphisms and attentional bias in cocaine dependence. CPDD 72nd Annual Scientific Meeting, Scottsdale, Arizona.

David A Nielsen, W Huang, S C Hamon, L Maili, K A Cunningham, F G Moeller. (2010). Epigeneic effects of cocaine on white matter. CPDD 72nd Annual Scientific Meeting, Scottsdale, Arizona.

L. Maili, D. A. Nielsen, S. Lui, S. Hamon, K. A. Cunnigham, F. G. Moeller. (2010) The serotonin transporter and impulsivity in cocaine dependent individuals. Society for Neuroscience, San Diego CA.

Interaction of Specific Genetic Variants with Treatment Effectiveness in Disulfiram Pharmacotherapy for Cocaine Dependence. (2010). David Nielsen, Wen Huang, Mark Harding, Sara Hamon, Jan Lindsay, Thomas Kosten. America College of Neuropsychopharacology. Miami Beach, Florida.

D. Nielsen, S. Hamon, V. Yuferov, C. Jackson, A. Ho, J. Ott, M. J. Kreek
Ethnic diversity of OPRM1 gene promoter DNA methylation and its association with subjects in methadone treatment. (2009) CPDD 71st Annual Scientific Meeting Reno Nevada.

D.A. Nielsen, S. Hamon, V. Yuferov, C. Jackson, J. Ott, and M.J. Kreek. Ethnic dependence of CpG DNA methylation differences in the OPRM1 gene promoter region in lymphocytes in severe heroin addicts (2009) Keystone Symposium Epigenetics, Development and Human Disease Breckenridge, Colorado.

D. Nielsen, S. Hamon, C. Jackson, A. Ho, J. Ott, M. J. Kreek. Association of OPRM1 DNA methylation with CD4+ count in HIV infected women. (2009) International Narcotics Research Conference. Portland, Oregon.

Yuferov V, Hamon S, Levran O, Ho A, Ott J, Kreek MJ. Analysis of association of the 830 bp indel polymorphism in the OPRK1 promoter with cocaine dependence. (2009) The College on the Problems of Drug Dependence 71st Annual Scientific Meeting. Reno, Nevada.

D.A. Nielsen, V. Yuferov, S. Hamon, M. Rouault, C. Jackson, J. Ott, and M.J. Kreek, DNA methylation of CpG dinucleotides in the mu-opioid receptor gene promoter region occurs in vivo and is increased in lymphocytes of Caucasian former severe heroin addicts (2008) CPDD The College on the Problems of Drug Dependence 70th Annual Scientific Meeting. San Juan, Puerto Rico.

He C, Hamon S,Li D, Barral S,Ott J MHC fine-mapping of human type-1 diabetes using T1DGC data (2007) MHC Results Workshop meeting Washington, DC.

V. Yuferov, D. Hua, S.C. Hamon, J. Ott, M.J. Kreek Gender differences in association of the hPer2 gene polymorphisms with cocaine dependence (2006) The College on the Problems of Drug Dependence. Scottsdale, Arizona.

Hamon SC, Kardia SLR, Boerwinkle E, Liu K, Klos KL, Clark AG, Sing CF. Replicate evidence for intragenic and intergenic interactions between SNP polymorphisms in the APOA1/C3/A4/A5 gene cluster. (2004) The American Society of Human Genetics 54th Annual Meeting. Toronto, Canada.

Stengard JH, Kardia SLR, Hamon S, Clark A, Boerwinkle E, Salomaa V, Tybjaerg-Hansen A, Frikke-Schmidt R, Sing CF. (2004) Variation in 5' region contributes significantly to pleiotropic effects of the apoE gene on multiple measures of lipid metabolism. European Atherosclerosis Society 74th EAS Congress. Seville, Spain

Sing C, Hamon S, Clark A, Nickerson D, Weiss K, Stengard J, Boerwinkle E, Kardia S. (2002) ApoE, SNPs and Risk of Heart Disease. Genotype to Phenotype: Focus on Disease: Keystone Symposium. Santa Fe, NM.

Sing C, Hamon S, Nelson M, Clark A, Nickerson D, Weiss K, Stengard J, Boerwinkle E, Kardia S (2001) Identification of DNA sequence variations that influence variation in disease risk. International Symposium on New Avenues in Atherosclerosis Research: Genomics and New Therapeutical Perspectives. Montreal, Canada, March 14-15, 2001.

Hamon SC, Clark AG, Weiss KM, Nickerson DA, Boerwinkle E, Stengard JH, Sing CF (2001) Evidence for interaction between nucleotides within the apoE gene. The American Society of Human Genetics 51st Annual Meeting. San Diego, CA, October 12-16, 2001. Am J Hum Genet 69:183.

Sing C, Renner B, Hamon S, Clark A, Nickerson D, Weiss K, Stengard J, Boerwinkle E, Kardia S. (2001) Identification of DNA sequence variations that influence variation in disease risk. 4th International Meeting on Single Nucleotide Polymorphisms and Complex Genome Analysis. Stockholm, Sweden, October 10-13, 2001.